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The Kansas City Chiefs defeated the New York Giants 22-9 in a dominant performance led by Patrick Mahomes. The Chiefs' defense forced two interceptions from Russell Wilson, while Mahomes efficiently moved the ball and found the end zone twice. Rookie Cam Skattebo scored the Giants' only touchdown in a losing effort.
September 22, 2025
The San Francisco 49ers defeated the Arizona Cardinals 16-15 in a defensive game featuring Christian McCaffrey's continued comeback, Kyler Murray's connection with Try McBride, and a dramatic game-winning field goal in the final seconds.
The Chicago Bears dominated the Dallas Cowboys 31-14 behind a spectacular performance from quarterback Caleb Williams, who threw for 298 yards and 4 touchdowns. Rookie Luther Burden III had a breakout game with 101 receiving yards and a touchdown, while the Bears' new offensive system under Ben Johnson looked unstoppable.
The Seattle Seahawks dominated the New Orleans Saints 44-13 at home, showcasing their new run-heavy offense led by Kenneth Walker and Sam Darnold. Tyler Horton's 95-yard punt return touchdown highlighted the explosive plays, while Spencer Rattler and Chris Olave tried to keep the Saints competitive despite the lopsided score.
The Los Angeles Chargers defeated the Denver Broncos 23-20 in an AFC West showdown. Rookie Omarion Hampton led the Chargers' ground attack while Justin Herbert threw the game-tying touchdown to Keenan Allen. Denver's Bo Nix connected with Courtland Sutton for a spectacular 52-yard touchdown, but Cameron Dicker's game-winning field goal sealed the victory for Los Angeles.
The Pittsburgh Steelers defeated the New England Patriots 21-14 in a game featuring Aaron Rodgers' debut with Pittsburgh and Drake Maye's continued development. The Steelers led early behind Jaylen Warren's powerful running and a touchdown pass from Rodgers to new receiver DK Metcalf. The Patriots fought back with two touchdown passes from Maye to Hunter Henry, but Calvin Austin III's late touchdown catch sealed the victory for Pittsburgh.
The Minnesota Vikings dominated the Cincinnati Bengals 48-10 at home, with Jordan Mason rushing for 116 yards and 2 TDs while Ivan Rodgers returned an interception and fumble for touchdowns. The victory showcased Minnesota's Super Bowl potential while highlighting Cincinnati's struggles without injured QB Joe Burrow.
The Indianapolis Colts dominated the Tennessee Titans 41-20 behind strong performances from Daniel Jones and Jonathan Taylor. Moore's pick-six started the scoring, while Taylor's 46-yard TD run sealed the victory. Rookie Cameron Ward showed flashes for Tennessee despite the loss.
Cleveland Browns defeated Green Bay Packers 13-10 in a defensive battle, with rookie Quinshon Judkins rushing for 94 yards and a touchdown while Joe Flacco managed the game effectively despite one interception.
The Washington Commanders defeated the Las Vegas Raiders 41-24 in an exciting offensive showcase, with Marcus Mariota leading the way and several explosive plays including a 90-yard punt return touchdown.
The Jacksonville Jaguars defeated the Houston Texans 17-10 in a defensive battle featuring Travis Etienne Jr.'s game-winning touchdown and strong performances by Nico Collins and Trevor Lawrence.
The Carolina Panthers dominated the Atlanta Falcons 30-0 behind a stellar defensive performance that included two interceptions of Michael Penix Jr. Bryce Young led Carolina's balanced attack while the defense completely shut down Atlanta's talented offense featuring Bijan Robinson and Drake London.